My disclaimer.....I inherited this infrastructure.

I want to enable Jumbo Frame.

I know how to Config jumbo frames on the m6220, EQL and The Power connect 5424(SAN ISCSI SWITCH)

It looks like on the M6220 in my chassis that they are NOT doing a LAP\ ether channel to the Power connect 5424 on the external switch ports connections on the M6220.

SHOULD I do a LAP from the M6220 to the 5424 or leave it with (4) 1 GB connections? I say LAP?

Once I enable Jumbo Frames I need to set my ESX 4 host to accept Jumbo frames and any other servers that connect using the ISCSI NIC's to Jumbo Frames.

Just need some confirmation and any other words of wisdom.

I don't know about the M6220 but the guide you want is

http://sites.google.com/site/mellerbeck/Home/ConfiguringVMwarevSphereSoftwareiSCSIwithDellEqualLogicPSSeriesStorageTR1049.pdf?attredirects=0&d=1

Or google configuringVMwarevSphereSoftwareiSCSIwithDellEqualogic

http://michaelellerbeck.com/2009/11/23/so-you-bought-an-equallogic-san-now-what-part-one/

-Michael