Do you have any security software (firewalls) that may be blocking the connection? If so, try temporarily disabling the firewalls and see if you can get it to work.
All firewalls, spyware, and virus protection are off and the mail is configured with the correct ports. The other weird thing is that I can ping the router and any website. Also, if I go into safemode, everything works fine. There seems to be some settings that prevents using the internet and sending mail in the regular mode???
We also use the computer for broadband via satellite. Maybe there are there potential settings for the satellite that is preventing DSL/ethernet from working correctly????
If it works in Safe Mode, that suggest that something is loading from startup that is blocking the internet connection. Go to Start > Run and type msconfig then hit the Enter key. Look at all programs that have the box checked. Which ones are listed?
The glitch is most likely spyware that has infected your computer. Download, install, update, and run the free versions of Ad-Aware and Spybot and let these programs remove all of the garbage that they find.If these programs don't solve the problem, go Here and follow the directions to download and run the analysis tool called HijackThis. Generate a log file, then open it and copy and paste the text of the log file in a message in the HijackThis forum where a HijackThis expert can offer advice on how to fix the problem.