The same problem just happened to me a day ago. At first I thought it was a stuck keyboard.
I found this post. Thank you very much.
With the mouse on, it was impossible to get to any setup screens.
I turned off the mouse and used the keyboard without any problem.
I'm buying a USB directly connected mouse.
I'm sure this has more than one cause but for me, I solved it by putting in a new keyboard ($10 with free postage & so easy to do) on my Acer 5733 laptop. The keyboard cable had been short circuited by a liquid spill.