dear colleagues,
I suffered from this problem as well (E6400, 2x2GB Ram, NVS 160M, 250GB 7200rpm drive) - from January 2009 to yesterday (FOUR MONTHS!!).
I have finally solved it. It's not a driver issue or bios issue (or OS / Software), it's definitely hardware problem. DELL changed motherboard on my notebook at first. Of course, this didn't helped. Then HDD, because the old one crashed (I think because of enormous heat inside the system). I got HITACHI drive instead of SEAGATE. This helped a little bit, HITACHI is not causing so much heat. Then I figured out, that after changing of HDD and removing one memory from slot (running just with 2gb) I'm able to work at home (without E-PORT and ext. Monitors) without this slow down.
After again and again describing the problem to DELL with all the combinations I tried (close lid, open lid, E-PORT / without E-PORT / just one memory module, new cooler HDD etc) they finally agreed to change EVERYTHING (again motherboard, CPU, memory and cooling system).
The problem is gone. Whole system is running cooler now, not so noisy - FAN is running at 2800 rpm most of the time (even with BOINC running all the time), not 4800 rpm as before, you can't feel heat on keyboard, the temperature of GPU chip is not attacking 100C, it's like brand new model.
I think, the problem was at cooling subsystem. The copper pipe is filled with some liquid and DELL technician confirmed me, that sometimes happens, that there is no fluid at all, or much less, than should be.
All of you should definitely call DELL and ask for changing of the components. Again, it is DELL HW issue.
I hope this info will help all of you and at the end you will enjoy your DELL notebook the same way, as me.
best regards,
mk